If you’re like me and have both ASP.NET 1.1 and 2.0 on your machine (along with the associated Visual Studio 2003 and 2005 products because you can’t help but write software in both environments) you may encounter this issue. Upon running your website (via http://localhost/xxx or something like that), you may encounter the error page that reports:
Failed to access IIS metabase
If so, you may have installed IIS after installing the .NET framework. If that’s the case, try running to repair your ASP.NET installation and set up all of the appropriate ISAPI extension mappings.
If, however, you’re like me and had IIS already installed, and you installed VS 2003 and then VS 2005, and then set up a 1.1 virtual directory / website, simply check that the appropriate ASP.NET version is associated with it (Select VDIR –> Properties –> ASP.NET tab).